Development of taladegib as a sonic hedgehog signaling pathway inhibitor

Arch Pharm Res. 2017 Dec;40(12):1390-1393. doi: 10.1007/s12272-017-0987-x. Epub 2017 Nov 20.
No abstract available

Publication types

  • Review

MeSH terms

  • Animals
  • Antineoplastic Agents / chemical synthesis
  • Antineoplastic Agents / pharmacology
  • Antineoplastic Agents / therapeutic use
  • Drug Discovery / methods
  • Drug Discovery / trends*
  • Hedgehog Proteins / antagonists & inhibitors*
  • Hedgehog Proteins / metabolism
  • Humans
  • Neoplasms / drug therapy
  • Neoplasms / metabolism
  • Phthalazines / chemical synthesis
  • Phthalazines / pharmacology*
  • Phthalazines / therapeutic use
  • Signal Transduction / drug effects*
  • Signal Transduction / physiology

Substances

  • Antineoplastic Agents
  • Hedgehog Proteins
  • LY2940680
  • Phthalazines