NSD3 keeps IRF3 active

Takashi Mino; Osamu Takeuchi

doi:10.1084/jem.20171980

NSD3 keeps IRF3 active

J Exp Med. 2017 Dec 4;214(12):3475-3476. doi: 10.1084/jem.20171980. Epub 2017 Nov 20.

Authors

Takashi Mino¹, Osamu Takeuchi¹

Affiliation

¹ Laboratory of Infection and Prevention, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan; Japan Agency for Medical Research and Development-Core Research for Evolutional Medical Science and Technology (AMED-CREST), Tokyo, Japan.

Abstract

In this issue of JEM, Wang et al. (https://doi.org/10.1084/jem.20170856) show a novel antiviral innate mechanism by which methyltransferase NSD3 directly monomethylates a transcription factor IRF3 and maintains IRF3 phosphorylation to enhance its transcriptional activity, consequently promoting antiviral innate immune responses.

Publication types

Comment

MeSH terms

Antiviral Agents*
Immunity, Innate
Interferon Regulatory Factor-3
Lysine*
Methylation
Methyltransferases

Substances

Antiviral Agents
Interferon Regulatory Factor-3
Methyltransferases
Lysine