Ca2+ leak-What is it? Why should we care? Can it be managed?

Heart Rhythm. 2018 Apr;15(4):607-614. doi: 10.1016/j.hrthm.2017.11.018. Epub 2017 Nov 20.

Abstract

For arrhythmia triggers that are secondary to dysfunctional intracellular Ca2+ cycling, there are few, if any, agents that specifically target the Ca2+ handling machinery. However, several candidates have been proposed in the literature. Here we review the idea that these agents or their derivatives will prove invaluable in clinical applications in the future.

Keywords: Arrhythmia; Calcium; Delayed afterdepolarization; Pharmacology; Trigger.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Anti-Arrhythmia Agents / pharmacology*
  • Arrhythmias, Cardiac / drug therapy*
  • Arrhythmias, Cardiac / metabolism
  • Arrhythmias, Cardiac / pathology
  • Calcium / metabolism*
  • Humans
  • Myocytes, Cardiac / metabolism*
  • Myocytes, Cardiac / pathology
  • Ryanodine Receptor Calcium Release Channel / metabolism*
  • Sarcoplasmic Reticulum / metabolism*
  • Sarcoplasmic Reticulum / pathology

Substances

  • Anti-Arrhythmia Agents
  • Ryanodine Receptor Calcium Release Channel
  • Calcium