Abstract
For arrhythmia triggers that are secondary to dysfunctional intracellular Ca2+ cycling, there are few, if any, agents that specifically target the Ca2+ handling machinery. However, several candidates have been proposed in the literature. Here we review the idea that these agents or their derivatives will prove invaluable in clinical applications in the future.
Keywords:
Arrhythmia; Calcium; Delayed afterdepolarization; Pharmacology; Trigger.
Copyright © 2017 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved.
Publication types
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Research Support, N.I.H., Extramural
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Review
MeSH terms
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Animals
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Anti-Arrhythmia Agents / pharmacology*
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Arrhythmias, Cardiac / drug therapy*
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Arrhythmias, Cardiac / metabolism
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Arrhythmias, Cardiac / pathology
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Calcium / metabolism*
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Humans
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Myocytes, Cardiac / metabolism*
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Myocytes, Cardiac / pathology
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Ryanodine Receptor Calcium Release Channel / metabolism*
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Sarcoplasmic Reticulum / metabolism*
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Sarcoplasmic Reticulum / pathology
Substances
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Anti-Arrhythmia Agents
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Ryanodine Receptor Calcium Release Channel
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Calcium