Pathology of Castleman Disease

David Wu; Megan S Lim; Elaine S Jaffe

doi:10.1016/j.hoc.2017.09.004

Pathology of Castleman Disease

Hematol Oncol Clin North Am. 2018 Feb;32(1):37-52. doi: 10.1016/j.hoc.2017.09.004.

Authors

David Wu¹, Megan S Lim², Elaine S Jaffe³

Affiliations

¹ Department of Laboratory Medicine, University of Washington, 825 Eastlake Avenue East, Room G-7800, Seattle, WA 98109, USA. Electronic address: dwu2@uw.edu.
² Department of Pathology and Laboratory Medicine, Perelman School of Medicine University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA.
³ Laboratory of Pathology, Hematopathology Section, Center for Cancer Research, National Cancer Institute, 10 Center Drive, Room 3S 235, Bethesda, MD 20892, USA.

PMID: 29157618
DOI: 10.1016/j.hoc.2017.09.004

Abstract

The term Castleman disease encompasses several distinct lymphoproliferative disorders with different underlying disease pathogenesis, and clinical outcomes. It includes unicentric and multicentric diseases with limited versus significant systemic symptoms, respectively. Importantly, the histopathologic features encountered in the various forms of Castleman disease are diverse, and for the most part, lack specificity, because they are seen to varying degrees in different clinical variants of Castleman disease, and in reactive (autoimmune/infectious) and malignant (lymphoma) contexts. Accordingly, accurate clinical diagnosis of Castleman disease requires careful and thorough clinicopathologic correlation. An overview of the key histopathologic features of Castleman disease is presented.

Keywords: Castleman disease; HHV8/KSHV; Hyaline-vascular; Hypervascular; Pathology; Plasmacytic features; TAFRO.

Publication types

Review

MeSH terms

Castleman Disease / classification*
Castleman Disease / diagnosis*
Castleman Disease / pathology*
Humans