New Concepts Related to Disease Appreciation in Multiple Sclerosis

Christina J Azevedo; Amirhossein Jaberzadeh; Daniel Pelletier

doi:10.1016/j.ncl.2017.08.010

New Concepts Related to Disease Appreciation in Multiple Sclerosis

Neurol Clin. 2018 Feb;36(1):119-133. doi: 10.1016/j.ncl.2017.08.010.

Authors

Christina J Azevedo¹, Amirhossein Jaberzadeh², Daniel Pelletier²

Affiliations

¹ Department of Neurology, Keck School of Medicine, University of Southern California, 1540 Alcazar Street, Suite 206, Los Angeles, CA 90033, USA. Electronic address: cazevedo@usc.edu.
² Department of Neurology, Keck School of Medicine, University of Southern California, 1540 Alcazar Street, Suite 206, Los Angeles, CA 90033, USA.

PMID: 29157393
DOI: 10.1016/j.ncl.2017.08.010

Abstract

In the past several decades, MRI has become an indispensable tool in the field of multiple sclerosis (MS) for clinicians and researchers. However, the MS field still faces several challenges. This review focuses on 2 current areas of difficulty: 1) discriminating MS from other diseases when the clinical history and imaging features are atypical or nonspecific, and 2) the lack of quantitative imaging metrics with which to follow MS patients over time in clinical practice. This review highlights promising MRI and postprocessing techniques that have potential applications in these areas. With further study, these tools could be usefully integrated into clinical care.

Keywords: Brain volumetrics; Central vein imaging; Cortical lesions; Image subtraction; Lesion probability mapping; MRI; Multiple sclerosis; Neuroimaging.

Publication types

Review

MeSH terms

Humans
Magnetic Resonance Imaging / methods*
Multiple Sclerosis / diagnostic imaging*
Neuroimaging / methods*