Clinical risk reclassification at 10 years

Nancy R Cook; Olga V Demler; Nina P Paynter

doi:10.1002/sim.7340

Clinical risk reclassification at 10 years

Stat Med. 2017 Dec 10;36(28):4498-4502. doi: 10.1002/sim.7340.

Authors

Nancy R Cook¹, Olga V Demler¹, Nina P Paynter¹

Affiliation

¹ Harvard Medical School, Brigham & Women's Hospital, Boston, MA, 02215, U.S.A.

Abstract

Three papers in this issue focus on the role of calibration in model fit statistics, including the net reclassification improvement (NRI) and integrated discrimination improvement (IDI). This commentary reviews the development of such reclassification statistics along with more recent advances in our understanding of these measures. We show how the two-category NRI and the IDI are affected by changes in the event rate in theory and in an applied example. We also describe the role of calibration and how it may be assessed. Finally, we discuss the relevance of the event rate NRI for clinical use. Copyright © 2017 John Wiley & Sons, Ltd.

Keywords: calibration; clinical utility; reclassification.

Publication types

Review

MeSH terms

Area Under Curve
Biomarkers
Biometry / methods*
Calibration
Cardiovascular Diseases
Computer Simulation
Female
Humans
Male
Risk Assessment / methods*
Risk Factors

Substances

Biomarkers

Abstract

Publication types

MeSH terms

Substances

Grants and funding