Perillyl alcohol alleviates amyloid-β peptides-induced mitochondrial dysfunction and cytotoxicity in SH-SY5Y cells

Mohammad Faraz Zafeer; Fakiha Firdaus; Faraz Ahmad; Rizwan Ullah; Ehraz Anis; Mohd Waseem; Asif Ali; Mohammad Mobarak Hossain

doi:10.1016/j.ijbiomac.2017.11.082

Perillyl alcohol alleviates amyloid-β peptides-induced mitochondrial dysfunction and cytotoxicity in SH-SY5Y cells

Int J Biol Macromol. 2018 Apr 1:109:1029-1038. doi: 10.1016/j.ijbiomac.2017.11.082. Epub 2017 Nov 14.

Authors

Mohammad Faraz Zafeer¹, Fakiha Firdaus², Faraz Ahmad³, Rizwan Ullah⁴, Ehraz Anis⁵, Mohd Waseem⁶, Asif Ali⁷, Mohammad Mobarak Hossain⁵

Affiliations

¹ Interdisciplinary Brain Research Centre, Faculty Of Medicine, Aligarh Muslim University, Aligarh, U.P, India. Electronic address: faraz.zafeer@gmail.com.
² Interdisciplinary Brain Research Centre, Faculty Of Medicine, Aligarh Muslim University, Aligarh, U.P, India; Department Of Zoology, Faculty Of Life Sciences, Aligarh Muslim University, Aligarh, U.P, India.
³ Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh, U.P, India.
⁴ Department Of Zoology, Faculty Of Life Sciences, Aligarh Muslim University, Aligarh, U.P, India.
⁵ Interdisciplinary Brain Research Centre, Faculty Of Medicine, Aligarh Muslim University, Aligarh, U.P, India.
⁶ Department of Medical Elementology and Toxicology, Jamia Hamdard (Hamdard University), Hamdard Nagar, New Delhi, 110062, India.
⁷ Interdisciplinary Brain Research Centre, Faculty Of Medicine, Aligarh Muslim University, Aligarh, U.P, India; Department of Biochemistry, JN Medical College, Faculty of Medicine, Aligarh Muslim University, Aligarh, 202002, India.

PMID: 29154879
DOI: 10.1016/j.ijbiomac.2017.11.082

Abstract

Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the most common type of dementia in elderly ( >65years of age). Excessive extra cellular deposits of amyloid beta (Aβ) are a pathological feature of AD. Aβ can cause cell death through oxidative damage; recent studies have implicated opening of mPTP as a detrimental event in AD-related mitochondrial dysfunctions. Over the past few years, natural compounds with antioxidant properties have shown promise for intervention in AD.

MeSH terms

Amyloid beta-Peptides / pharmacology*
Apoptosis / drug effects
Cell Line, Tumor
Cell Survival / drug effects
Cytochromes c / metabolism
DNA Fragmentation / drug effects
Drug Synergism
Humans
Ion Channel Gating / drug effects
Membrane Potential, Mitochondrial / drug effects
Mitochondria / drug effects*
Mitochondria / metabolism*
Mitochondrial Membrane Transport Proteins / metabolism
Mitochondrial Permeability Transition Pore
Monoterpenes / pharmacology*
Reactive Oxygen Species / metabolism

Substances

Amyloid beta-Peptides
Mitochondrial Membrane Transport Proteins
Mitochondrial Permeability Transition Pore
Monoterpenes
Reactive Oxygen Species
perillyl alcohol
Cytochromes c