The genetics of Kawasaki disease

Int J Rheum Dis. 2018 Jan;21(1):26-30. doi: 10.1111/1756-185X.13218. Epub 2017 Nov 19.

Abstract

Kawasaki disease (KD) is a complex disorder which affects genetically susceptible infants and children. Several susceptibility genes (e.g., ITPKC, CASP3, CD40 and ORAI) and chromosomal regions have been identified through genome-wide association and genome-wide linkage studies to have association with KD. Knowledge of susceptibility genes involved in the pathogenesis of KD may provide new insights into diagnosis and treatment of this condition. However, there is much that we still do not know about the genetic basis of KD.

Keywords: Kawasaki disease; genetic variants; susceptibility gene.

Publication types

  • Review

MeSH terms

  • Age of Onset
  • Child, Preschool
  • Genetic Predisposition to Disease
  • Genetic Variation*
  • Genome-Wide Association Study
  • Humans
  • Infant
  • Mucocutaneous Lymph Node Syndrome / diagnosis
  • Mucocutaneous Lymph Node Syndrome / ethnology
  • Mucocutaneous Lymph Node Syndrome / genetics*
  • Mucocutaneous Lymph Node Syndrome / immunology
  • Mutation
  • Phenotype
  • Risk Factors