Genetic analysis of 29 Y-STR loci in the Chinese Han population from Shanghai

Yuxiang Zhou; Chengchen Shao; Liming Li; Yaqi Zhang; Baonian Liu; Qinrui Yang; Qiqun Tang; Shilin Li; Jianhui Xie

doi:10.1016/j.fsigen.2017.11.003

Genetic analysis of 29 Y-STR loci in the Chinese Han population from Shanghai

Forensic Sci Int Genet. 2018 Jan:32:e1-e4. doi: 10.1016/j.fsigen.2017.11.003. Epub 2017 Nov 11.

Authors

Yuxiang Zhou¹, Chengchen Shao¹, Liming Li², Yaqi Zhang¹, Baonian Liu¹, Qinrui Yang¹, Qiqun Tang³, Shilin Li², Jianhui Xie⁴

Affiliations

¹ Department of Forensic Medicine, Shanghai Medical College of Fudan University, Shanghai, 200032, China.
² Ministry of Education Key Laboratory of Contemporary Anthropology and State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Shanghai, 200433, China.
³ Department of Biochemistry and Molecular Biology, Shanghai Medical College of Fudan University, Shanghai, 200032, China.
⁴ Department of Forensic Medicine, Shanghai Medical College of Fudan University, Shanghai, 200032, China. Electronic address: jhxie@fudan.edu.cn.

PMID: 29150183
DOI: 10.1016/j.fsigen.2017.11.003

Abstract

The analysis of Y chromosomal short tandem repeats (Y-STRs) provides important information that can be used to forensic investigation and population studies. In this study, typing of 29 Y-STRs included in the PowerPlex^® Y23 system (PPY23) and Yfiler™ Plus system (Yfiler plus) was performed on 843 unrelated male samples from Han population in Shanghai. Besides null, duplicate, and intermediate alleles reported in previous studies, an allele of 10 at DYS643 with a 2-base deletion in the flanking region was initially observed. The gene diversity (GD) values of the 29 Y-STRs range from 0.4186 at DYS438 to 0.9653 at DYS385a/b. The haplotype diversity of two commonly used haplotype sets, PPY23 set and Yfiler plus set is 0.999980 and 0.999997, respectively. Pairwise genetic distances between Han population in Shanghai and other Han populations estimated using Yfiler plus set are slightly larger than that between other Han populations. Visualization of pairwise genetic distances between 17 worldwide populations using multidimensional scaling (MDS) demonstrates the distribution of populations according to their ethno-geographic patterns. Compared with Yfiler set, Yfiler plus set appears to have a relatively high population discrimination capacity for these tested populations. Altogether, these results can provide useful information of Y-STRs for forensic investigation and population studies.

Keywords: Forensic genetics; Han population; PowerPlex(®) Y23 system; Y chromosomal short tandem repeats; Yfiler™ plus system.

MeSH terms

China
Chromosomes, Human, Y*
DNA Fingerprinting
Ethnicity / genetics*
Gene Frequency
Genetic Variation
Genetics, Population*
Genotype
Haplotypes
Humans
Male
Microsatellite Repeats*
Polymerase Chain Reaction