Turning Over a New Leaf: Bacteriocins Going Green

Maarten G K Ghequire; René De Mot

doi:10.1016/j.tim.2017.11.001

Turning Over a New Leaf: Bacteriocins Going Green

Trends Microbiol. 2018 Jan;26(1):1-2. doi: 10.1016/j.tim.2017.11.001. Epub 2017 Nov 14.

Authors

Maarten G K Ghequire¹, René De Mot²

Affiliations

¹ Centre of Microbial and Plant Genetics, KU Leuven, Kasteelpark Arenberg 20 box 2460, 3001 Heverlee, Belgium. Electronic address: maarten.ghequire@biw.kuleuven.be.
² Centre of Microbial and Plant Genetics, KU Leuven, Kasteelpark Arenberg 20 box 2460, 3001 Heverlee, Belgium.

PMID: 29150081
DOI: 10.1016/j.tim.2017.11.001

Abstract

Bacteriocins are potent antibacterial proteins that selectively kill phylogenetic relatives of the producer. Their polymorphic nature, most prominent in γ-Proteobacteria, offers potential for the design of customized bacteriocin cocktails targeting Gram-negative pathogens. As an alternative to recombinant production in bacteria, they are eligible for large-scale production in plants.

Keywords: bacteriocin cocktail; colicin; plant-derived recombinant antimicrobials; protein engineering; pyocin.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Anti-Bacterial Agents / metabolism
Anti-Bacterial Agents / pharmacology
Bacteriocins / classification
Bacteriocins / genetics
Bacteriocins / metabolism*
Bacteriocins / pharmacology
Colicins / metabolism
Gram-Negative Bacteria / drug effects
Plant Leaves / genetics
Plant Leaves / metabolism*
Plants / genetics
Plants / metabolism*
Protein Engineering
Pyocins / metabolism
Recombinant Proteins / biosynthesis

Substances

Anti-Bacterial Agents
Bacteriocins
Colicins
Pyocins
Recombinant Proteins