Rheumatic Manifestations in Autoimmune Liver Disease

Rheum Dis Clin North Am. 2018 Feb;44(1):65-87. doi: 10.1016/j.rdc.2017.09.008.

Abstract

Autoimmune liver diseases coexist with rheumatic disorders in approximately 30% of cases and may also share pathogenic mechanisms. Autoimmune liver diseases result from an immune-mediated injury of different tissues, with autoimmune hepatitis (AIH) targeting hepatocytes, and primary biliary cholangitis (PBC) and primary sclerosing cholangitis targeting cholangiocytes. Sjogren syndrome is diagnosed in 7% of AIH cases and serologic autoimmunity profiles are a common laboratory abnormality, particularly in the case of serum antimitochondrial (PBC) or anti-liver kidney microsomal antibodies (AIH). Therapeutic strategies may overlap between rheumatic and autoimmune liver diseases and practitioners should be vigilant in managing bone loss.

Keywords: Autoantibody; Autoimmune comorbidity; Cholangitis; Hepatitis; Immune tolerance; Methotrexate; Osteoporosis; Personalized medicine.

Publication types

  • Review

MeSH terms

  • Autoimmunity / genetics
  • Diagnosis, Differential
  • Genetic Predisposition to Disease
  • Hepatitis, Autoimmune* / diagnosis
  • Hepatitis, Autoimmune* / etiology
  • Hepatitis, Autoimmune* / immunology
  • Humans
  • Precision Medicine
  • Rheumatic Diseases* / diagnosis
  • Rheumatic Diseases* / etiology
  • Rheumatic Diseases* / immunology