1 Medical Sciences Division, University of Oxford, Level 3, John Radcliffe Hospital, Oxford OX3 9DU, UK. gavin.screaton@medsci.ox.ac.uk j.mongkolsapaya@imperial.ac.uk.
2 Department of Medicine, Imperial College London, Commonwealth Building, Hammersmith Campus, Du Cane Road, London W12 0NN, UK. gavin.screaton@medsci.ox.ac.uk j.mongkolsapaya@imperial.ac.uk.