Eudesmane and aromadendrane sesquiterpenoids from the Vietnamese soft coral Sinularia erecta

Nat Prod Res. 2018 Aug;32(15):1798-1802. doi: 10.1080/14786419.2017.1402326. Epub 2017 Nov 16.

Abstract

Using various chromatographic separations, eight sesquiterpenoids (1-8), including one new compound 3β,5α-dihydroxyeudesma-4(15),11-diene (1), were isolated from the MeOH extract of the Vietnamese soft coral Sinularia erecta. The structure elucidation was confirmed by spectroscopic experiments including 1D and 2D NMR and HR-ESI-MS. The cytotoxic activities against three human cancer cell lines (A-549, HeLa and PANC-1) of all isolated compounds were evaluated by MTT-based colorimetric assays. Compound 1 exhibited selective cytotoxicity against the A549 cell line with IC50 of 14.79 ± 0.91 μM.

Keywords: Sinularia erecta; aromadendrane; cytotoxicity; eudesmane; sesquiterpenoid.

MeSH terms

  • Animals
  • Anthozoa / chemistry*
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology*
  • Cell Line, Tumor
  • Drug Screening Assays, Antitumor
  • HeLa Cells
  • Humans
  • Inhibitory Concentration 50
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Sesquiterpenes / chemistry
  • Sesquiterpenes / pharmacology*
  • Sesquiterpenes, Eudesmane / chemistry
  • Sesquiterpenes, Eudesmane / pharmacology*
  • Sesquiterpenes, Guaiane

Substances

  • Antineoplastic Agents
  • Sesquiterpenes
  • Sesquiterpenes, Eudesmane
  • Sesquiterpenes, Guaiane
  • aromadendrane
  • eudesmane