A Survey of the Neuro-Oncology Landscape

Rimas V Lukas; Jing Wu; Mahua Dey; Robin A Buerki; Richard W Byrne; George J Dohrmann

doi:10.3988/jcn.2018.14.1.8

A Survey of the Neuro-Oncology Landscape

J Clin Neurol. 2018 Jan;14(1):8-15. doi: 10.3988/jcn.2018.14.1.8. Epub 2017 Oct 31.

Authors

Rimas V Lukas¹, Jing Wu², Mahua Dey³, Robin A Buerki⁴, Richard W Byrne⁵, George J Dohrmann⁶

Affiliations

¹ Department of Neurology, Northwestern University, Chicago, IL, USA. rimas.lukas@nm.org.
² Neuro-Oncology Branch, National Institutes of Health, Bethesda, MD, USA.
³ Department of Neurosurgery, Indiana University, Indianapolis, IN, USA.
⁴ Department of Neurosurgery, University of California, San Francisco, CA, USA.
⁵ Department of Neurosurgery, Rush University, Chicago, IL, USA.
⁶ Section of Neurosurgery, University of Chicago, Chicago, IL, USA.

Abstract

The field of neuro-oncology is evolving rapidly. Many important advances have recently been reported, and other promising investigations have the potential to soon make substantial impacts in the field, especially in the areas of high-grade gliomas and brain metastases. We present an overview of the current status of this field, highlighting the key recent advances as well as representative work of key clinical investigations, since these concepts have the potential to influence clinical management if they are demonstrated to be safe and efficacious. This overview includes some work that has only appeared in abstract form in order to provide a timely understanding of how the field is actively changing and what may lie on the horizon. We focus on both medical and surgical neuro-oncology advances in this highly multidisciplinary subspecialty.

Keywords: brain metastases; gene therapy; glioma; isocitrate dehydrogenase; laser ablation; neuro-oncology; neurosurgery; tumor treating fields; viral therapy.

Publication types

Review