Abstract
Twenty-eight protostane triterpenoids, including a new degraded one (1), nine new ones (2 - 10), and two new natural ones (11 and 12), have been isolated from the dried rhizomes of Alisma orientale. Alisol R (1) was the first 20,21,22,23,24,25,26,27-octanorprotostane triterpenoid. The absolute configurations of 25-methoxyalisol F (2) and 16β-hydroperoxyalisol B 23-acetate (3) were determined by X-ray diffraction analysis. In addition, alismaketone-B 23-acetate (28) showed potent vasorelaxant activity on endothelium-intact thoracic aorta rings precontracted with KCl.
Keywords:
Alisma orientale; Alismataceae; Alismatis Rhizoma; Protostane triterpenoids; Vasorelaxant activity.
© 2017 Wiley-VHCA AG, Zurich, Switzerland.
MeSH terms
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11-beta-Hydroxysteroid Dehydrogenases / antagonists & inhibitors
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11-beta-Hydroxysteroid Dehydrogenases / metabolism
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Alisma / chemistry*
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Alisma / metabolism
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Animals
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Aorta / drug effects
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Aorta / metabolism
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Humans
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Magnetic Resonance Spectroscopy
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Mice
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Molecular Conformation
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Plant Extracts / chemistry
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Potassium Chloride / toxicity
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Rats
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Rhizome / chemistry
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Rhizome / metabolism
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Terpenes / chemistry*
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Terpenes / metabolism
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Terpenes / pharmacology
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Triterpenes / chemistry
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Triterpenes / isolation & purification
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Triterpenes / pharmacology
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Vasodilator Agents / chemistry
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Vasodilator Agents / isolation & purification
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Vasodilator Agents / pharmacology
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X-Ray Diffraction
Substances
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Plant Extracts
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Terpenes
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Triterpenes
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Vasodilator Agents
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alismaketone-B 23-acetate
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Potassium Chloride
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11-beta-Hydroxysteroid Dehydrogenases