CXCL6 promotes non-small cell lung cancer cell survival and metastasis via down-regulation of miR-515-5p

Jun Li; Zhiyuan Tang; Haiying Wang; Wei Wu; Fengqiu Zhou; Honggang Ke; Wei Lu; Shu Zhang; Yanju Zhang; Si Yang; Songshi Ni; Jianan Huang

doi:10.1016/j.biopha.2017.11.004

CXCL6 promotes non-small cell lung cancer cell survival and metastasis via down-regulation of miR-515-5p

Biomed Pharmacother. 2018 Jan:97:1182-1188. doi: 10.1016/j.biopha.2017.11.004. Epub 2017 Nov 11.

Authors

Jun Li¹, Zhiyuan Tang², Haiying Wang², Wei Wu³, Fengqiu Zhou², Honggang Ke⁴, Wei Lu⁵, Shu Zhang⁶, Yanju Zhang², Si Yang², Songshi Ni², Jianan Huang⁷

Affiliations

¹ Department of Respiratory, First Affiliated Hospital of Soochow University, Suzhou, China; Department of Respiratory, Affiliated Hospital of Nantong University, Nantong, China.
² Department of Respiratory, Affiliated Hospital of Nantong University, Nantong, China.
³ Research Center of Clinical Medicine, Affiliated Hospital of Nantong University, Nantong, China.
⁴ Department of Thoracic Surgery, Affiliated Hospital of Nantong University, Nantong, China.
⁵ Department of Hematology, Affiliated Hospital of Nantong University, Nantong, China.
⁶ Department of Pathology, Affiliated Hospital of Nantong University, Nantong, China.
⁷ Department of Respiratory, First Affiliated Hospital of Soochow University, Suzhou, China. Electronic address: jianan-h@tom.com.

PMID: 29136957
DOI: 10.1016/j.biopha.2017.11.004

Abstract

Chemokine plays an important role in lung cancer and CXCL6 is one of chemokine, however, its effect on miRNAs profile and its roles in non-small cell lung cancer cell (NSCLC) is not elucidated. This study is purposed to explore the influence of CXCL6 on miRNA expression profile and found that CXCL6 could reduce the expression of miR-515-5p in NSCLC cells. MiR-515-5p in NSCLC cells could inhibit NSCLC survival and metastasis. MiR-515-5p acted as a tumor suppressor by targeting CXCL6 in NSCLC cells. These data highlighted a novel molecular interaction between miR-515-5p and CXCL6. MiR-515-5p may constitute a potential therapy target for NSCLC.

Keywords: CXCL6; Metastasis; NSCLC; miR-515-5p.

MeSH terms

Carcinoma, Non-Small-Cell Lung / genetics
Carcinoma, Non-Small-Cell Lung / pathology*
Cell Line, Tumor
Cell Survival
Chemokine CXCL6 / metabolism*
Down-Regulation
Gene Expression Regulation, Neoplastic
Humans
Lung Neoplasms / genetics
Lung Neoplasms / pathology*
MicroRNAs / genetics*
Neoplasm Metastasis

Substances

CXCL6 protein, human
Chemokine CXCL6
MIRN515 microRNA, human
MicroRNAs