Interventional Therapies for the Treatment of Food Allergy

Immunol Allergy Clin North Am. 2018 Feb;38(1):77-88. doi: 10.1016/j.iac.2017.09.006. Epub 2017 Oct 23.

Abstract

Treatment of IgE-mediated food allergies is limited to allergen avoidance and emergency treatment on accidental ingestion, which is not uncommon. In recent years, interest in interventional therapies to treat food allergy has increased significantly. Although oral, sublingual, and epicutaneous immunotherapy have shown promise in studies, none is approved as therapy for food allergy to date and questions remain regarding efficacy, safety, dosing, and duration of therapy.

Keywords: EPIT; Epicutaneous immunotherapy; Food allergy treatment; IgE-mediated food allergy; OIT; Oral immunotherapy; SLIT; Sublingual immunotherapy.

Publication types

  • Review

MeSH terms

  • Administration, Oral
  • Allergens / immunology
  • Allergens / therapeutic use*
  • Animals
  • Desensitization, Immunologic / methods*
  • Food Hypersensitivity / therapy*
  • Humans
  • Immune Tolerance
  • Immunoglobulin E / metabolism
  • Sublingual Immunotherapy

Substances

  • Allergens
  • Immunoglobulin E