Food Protein-Induced Enterocolitis Syndrome

Abstract

Food protein-induced enterocolitis syndrome (FPIES) is a non-IgE-mediated food allergy that usually presents in infancy. Cow's milk, soy, and grains are the most common food triggers. FPIES can present as a medical emergency with symptoms including delayed persistent emesis or diarrhea that can lead to severe dehydration and hemodynamic instability with abnormal laboratory markers. Diagnosis can often be made based on clinical history and noted improvement in symptoms once the suspected triggers have been removed from the diet, with oral food challenge as the gold standard for confirmation of diagnosis in unclear cases.

Keywords: Cow’s milk; Failure to thrive; Food protein-induced enterocolitis syndrome (FPIES); Non-IgE–mediated food allergy; Oral food challenge; Soy.