HLA genes in Barranquilla (North Colombia): Searching for cryptic Amerindian genes

Hum Immunol. 2018 Jan;79(1):3-4. doi: 10.1016/j.humimm.2017.11.003. Epub 2017 Nov 9.

Abstract

America First Inhabitants population (Amerindians, Na Dene and Eskimos) underwent a drastic population reduction and gene exchange after Europeans and Africans arrival after 1492 AD. Barranquilla population may be a good model to study present day population admixture in South America. HLA-A, -B and -DRB1 DNA typing has been performed in 188 unrelated individuals originated in the area and speak Spanish language; they showed apparent European/African and mixed characters. HLA genetic European/African features were found and only 1.85% Amerindian one. This contrasts with neighboring Cuban population where 10% HLA Amerindian characters appear.

Keywords: African; Amerindian; Barranquilla; Caucasoid; Colombia; Cuba; HLA.

MeSH terms

  • Black People
  • Colombia
  • Cuba
  • Ethnicity
  • Gene Frequency
  • Genotype*
  • HLA-A Antigens / genetics*
  • HLA-B Antigens / genetics*
  • HLA-DRB1 Chains / genetics*
  • Humans
  • Indians, South American*
  • Inuit
  • Language
  • Socioeconomic Factors
  • White People

Substances

  • HLA-A Antigens
  • HLA-B Antigens
  • HLA-DRB1 Chains