Squamous Cell Carcinoma Transformation from EGFR-mutated Lung Adenocarcinoma: A Case Report and Literature Review

Clin Lung Cancer. 2018 Jan;19(1):e63-e66. doi: 10.1016/j.cllc.2017.10.005. Epub 2017 Oct 19.
No abstract available

Keywords: Acquired resistance; Histologic transformation; Non–small-cell lung cancer; Osimertinib; T790M.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Acrylamides
  • Adenocarcinoma / diagnosis*
  • Adenocarcinoma / pathology
  • Aged
  • Aniline Compounds
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
  • Biopsy
  • Carcinoma, Squamous Cell / diagnosis*
  • Carcinoma, Squamous Cell / pathology
  • Cell Transformation, Neoplastic
  • Drug Resistance, Neoplasm / genetics
  • ErbB Receptors / genetics
  • Humans
  • Lung Neoplasms / diagnosis*
  • Lung Neoplasms / pathology
  • Male
  • Mutation / genetics*
  • Neoplasm Metastasis
  • Piperazines / therapeutic use*
  • Tomography, X-Ray Computed

Substances

  • Acrylamides
  • Aniline Compounds
  • Piperazines
  • osimertinib
  • EGFR protein, human
  • ErbB Receptors