Research Advances of Calcium-and Integrin-binding Protein 1 in Tumors

Abstract

Calcium-and integrin-binding protein 1(CIB1),a member of calcium binding protein containing EF-hand domain,has been shown to bind a variety of signaling proteins. Interaction of CIB1 with its various binding partners provides valuable insight into potential mechanisms by which CIB1 may regulate diverse tumors characteristic biological process that range from adhesion,migration,cell survival,proliferation,and angiogenesis. CIB1 has also been implicated in both the increase and decrease of cell proliferation.CIB1 promoted cell proliferation and survival by adjusted tumor-associated extracellular regulated protein kinases 1/2(ERK1/2),phosphatidylinositol 3 kinase(PI-3K)/v-akt murine thymoma viral oncogene homolog-dependent signaling pathway,or increased cell migration by activating Src family kinases,protein kinase C,PI-3K,and ERK 1/2-mediated signaling pathway.CIB1 inhibited cell proliferation through inhibiting polo-like kinases 3(PLK3) activity.It also inhibits cell migration by binding to and activating p21-activated kinase 1. Especially a large subset of triple-negative breast cancer may display non-oncogene addiction to CIB1,a phenomenon in which cancer cells require,or become 'addicted' to a non-mutated,non-overexpressed gene/protein that is nonetheless essential to maintain oncogenic signaling pathways,and implicate CIB1 as a novel drug target in tumors. Additionally,CIB1 plays a role in such pathological processes as cardiac hypertrophy,deafness,and male infertility. Research on CIB1 function has important clinical significance. In this review,we discussed current understanding of CIB1 in human tumors.