Brain volumetric analysis and cortical thickness in adults with saccadic intrusions (ocular flutter or opsoclonus-myoclonus syndrome)

María-José Ibáñez-Juliá; Evangelia Pappa; Bertrand Gaymard; Delphine Leclercq; Charlotte Hautefort; Caroline Tilikete; Jean-Yves Delattre; Khê Hoang-Xuan; Dimitri Psimaras; Agusti Alentorn

doi:10.1016/j.clineuro.2017.10.028

Brain volumetric analysis and cortical thickness in adults with saccadic intrusions (ocular flutter or opsoclonus-myoclonus syndrome)

Clin Neurol Neurosurg. 2017 Dec:163:167-172. doi: 10.1016/j.clineuro.2017.10.028. Epub 2017 Oct 31.

Affiliations

¹ Department of Neurology 2, Mazarin, Groupe Hospitalier Pitié-Salpêtrière, Assistance Publique Hôpitaux de Paris (AP-HP), 75013, Paris, France; Sorbonne Universités, Université Pierre et Marie Curie, Université Paris VI, 75013, Paris, France; Institut du Cerveau et de la Moelle Epinière, INSERM U1127 and Centre National de la Recherche Scientifique, Unité de Recherche Mixte, 7225, Paris, France.
² Deparment of Clinical Neurophysiology, Groupe Hospitalier Pitié-Salpêtrière, Assistance Publique Hôpitaux de Paris (AP-HP), 75013, Paris, France.
³ Department of Neuro-radiology, Groupe Hospitalier Pitié-Salpêtrière, Assistance Publique Hôpitaux de Paris (AP-HP), 75013, Paris, France.
⁴ Otolaryngology - Head and Neck Surgery Department, Hôpital Lariboisière, Assistance Publique Hôpitaux de Paris (AP-HP), 75475, Paris, France.
⁵ Neuro-Ophthalmology Unit, Lyon Civil Hospitals, Neurological Hospital, Lyon 1 University, Bron Cedex, France.
⁶ Department of Neurology 2, Mazarin, Groupe Hospitalier Pitié-Salpêtrière, Assistance Publique Hôpitaux de Paris (AP-HP), 75013, Paris, France; Sorbonne Universités, Université Pierre et Marie Curie, Université Paris VI, 75013, Paris, France; Institut du Cerveau et de la Moelle Epinière, INSERM U1127 and Centre National de la Recherche Scientifique, Unité de Recherche Mixte, 7225, Paris, France. Electronic address: agusti.alentorn@aphp.fr.

PMID: 29121544
DOI: 10.1016/j.clineuro.2017.10.028

Abstract

Objectives: Ocular flutter (OF) and opsoclonus are considered a continuum with a similar pathogenesis. Due to the rarity of this disease in the adult population, little is known about the brain morphological changes in the chronic phase of the disease.

Patients and methods: Six magnetic resonance imaging from adults with previous history of OF/Opsoclonus and 12 healthy patients (paired by age and sex) were analyzed in order to identify the long term cortical thickness pattern in this rare disease by using Freesurfer.

Results: Patients with OF/Opsoclonus showed reduced cerebellum cortical volume with a subsequent diminution in total cerebellar volume. White mater cerebellum volume was not modified. In addition, we have also identified a significant supratentorial gray matter volume decrease in OF/Opsoclonus patients, involving both the cortical and the subcortical gray matter.

Conclusions: OF/Opsoclonus in adults may be associated with cortical and subcortical gray matter atrophy, as well as decreased cerebellar cortical volume. Further larger prospective studies are necessary to confirm these results.

Keywords: Cerebellar atrophy; Cortical thickness; Ocular flutter; Opsoclonus myoclonus syndrome.

MeSH terms

Adult
Atrophy
Cerebellum / pathology*
Female
Gray Matter / pathology
Humans
Magnetic Resonance Imaging / methods
Male
Middle Aged
Ocular Motility Disorders / diagnosis
Ocular Motility Disorders / pathology*
Opsoclonus-Myoclonus Syndrome / diagnosis
Opsoclonus-Myoclonus Syndrome / pathology*
Prospective Studies
Saccades