Functional and Biochemical Parameters of Erythrocytes during Mexicor Treatment in Posttraumatic Period after Experimental Blood Loss and Combined Traumatic Brain Injury

Bull Exp Biol Med. 2017 Nov;164(1):26-29. doi: 10.1007/s10517-017-3918-4. Epub 2017 Nov 9.

Abstract

Mexicor treatment (8 mg/kg body weight per day) during the posttraumatic period after concomitant traumatic brain injury and acute blood loss in rats increased electrophoretic mobility and concentration of 2,3-diphosphoglycerate, and reduced malondialdehyde content in erythrocytes. These changes improved hemodynamics and oxygen-transporting function of the blood. The most pronounced effects of Mexicor were observed at the early stages of posttraumatic period.

Keywords: Mexicor; blood loss; traumatic brain injury.

MeSH terms

  • Animals
  • Brain Injuries, Traumatic / drug therapy*
  • Drug Evaluation, Preclinical
  • Erythrocytes / drug effects*
  • Female
  • Hematologic Agents / pharmacology
  • Hematologic Agents / therapeutic use*
  • Hemorrhage / drug therapy*
  • Pyridines / pharmacology
  • Pyridines / therapeutic use*
  • Rats

Substances

  • Hematologic Agents
  • Pyridines
  • ethylmethylhydroxypyridine succinate