Management, outcomes, and prognostic factors of ruptured hepatocellular carcinoma: A systematic review

Demetrios Moris; Jeffery Chakedis; Steven H Sun; Gaya Spolverato; Diamantis I Tsilimigras; Ioannis Ntanasis-Stathopoulos; Eleftherios Spartalis; Timothy M Pawlik

doi:10.1002/jso.24869

Management, outcomes, and prognostic factors of ruptured hepatocellular carcinoma: A systematic review

J Surg Oncol. 2018 Mar;117(3):341-353. doi: 10.1002/jso.24869. Epub 2017 Nov 8.

Authors

Demetrios Moris¹, Jeffery Chakedis¹, Steven H Sun¹, Gaya Spolverato¹, Diamantis I Tsilimigras², Ioannis Ntanasis-Stathopoulos², Eleftherios Spartalis³, Timothy M Pawlik¹

Affiliations

¹ Department of Surgery, The Ohio State University Wexner Medical Center and James Cancer Hospital and Solove Research Institute, Columbus, Ohio.
² Department of Therapeutics, Alexandra General Hospital, National and Kapodistrian University of Athens, Athens, Greece.
³ Laboratory of Experimental Surgery and Surgical Research, National and Kapodistrian University of Athens, Athens, Greece.

PMID: 29116644
DOI: 10.1002/jso.24869

Abstract

Ruptured hepatocellular (rHCC) is a rare but life-threatening presentation that often requires acute intervention. In this systematic review we identified 67 eligible studies reporting on 4941 patients with rHCC. Here we present the treatment approaches for the management of rHCC both in the acute setting with regards to management of hemorrhage, as well long-term with regards to oncological treatment.

Keywords: hepatocellular carcinoma; management; rupture; survival; systematic review.

Publication types

Review
Systematic Review

MeSH terms

Ablation Techniques
Carcinoma, Hepatocellular / pathology*
Carcinoma, Hepatocellular / surgery
Carcinoma, Hepatocellular / therapy*
Chemoembolization, Therapeutic
Female
Hepatectomy
Humans
Liver Neoplasms / pathology*
Liver Neoplasms / surgery
Liver Neoplasms / therapy*
Male
Middle Aged
Retrospective Studies
Rupture, Spontaneous
Treatment Outcome