Investigation of an elutable N-propylphosphonic acid chitosan derivative composition with a chitosan matrix prepared from carbonic acid solution

Szymon Mania; Robert Tylingo; Ewa Augustin; Katarzyna Gucwa; Jakub Szwacki; Hanna Staroszczyk

doi:10.1016/j.carbpol.2017.09.082

Investigation of an elutable N-propylphosphonic acid chitosan derivative composition with a chitosan matrix prepared from carbonic acid solution

Carbohydr Polym. 2018 Jan 1:179:196-206. doi: 10.1016/j.carbpol.2017.09.082. Epub 2017 Sep 25.

Authors

Szymon Mania¹, Robert Tylingo², Ewa Augustin³, Katarzyna Gucwa³, Jakub Szwacki⁴, Hanna Staroszczyk²

Affiliations

¹ Department of Chemistry, Technology and Biotechnology of Food, Gdansk University of Technology, Gabriela Narutowicza Street 11/12, Gdansk 80-233, Poland. Electronic address: szymon.mania@gmail.com.
² Department of Chemistry, Technology and Biotechnology of Food, Gdansk University of Technology, Gabriela Narutowicza Street 11/12, Gdansk 80-233, Poland.
³ Department of Pharmaceutical Technology and Biochemistry, Gdansk University of Technology, Gabriela Narutowicza Street 11/12, Gdansk 80-233, Poland.
⁴ Cambridge Innovation Center, Broadway FL14, Cambridge, MA 02142, United States.

PMID: 29111043
DOI: 10.1016/j.carbpol.2017.09.082

Abstract

Porous chitosan composites using CO₂ dissolution procedure and including water soluble N-propylphosphonic chitosan derivative (p-CHI) were obtained and characterized. In contrast to the control material, composites containing modified chitosan distinguished by a rapid moisture absorption and good adhesion to the skin. The FTIR analysis confirmed the presence of propylphosphonic group in the structure of the polymer. The porosity of the materials was in the range 55-77% and decreased with increasong amount of modified chitosan in materials. Solubility of composites was dependent on the content of p-CHI in scaffolds (40%, 25% and 15%) and reached values 11%, 9% and 6,5%, respectively. The values of other parameters like swelling degree (30g/g) good antioxidant and antimicrobial properties (almost 100% reduction of S.aureus, E.coli and C. albicans growth) and low in vitro cytotoxicity against fibroblasts were highly advantageous for possible biomedical applications of the composites.

Keywords: Antioxidant properties; Biocompatibility; Chitosan; Physico-chemical properties; Propylphosphonic acid adhydride.