Miniaturized high-performance liquid chromatography instrumentation

Kyle B Lynch; Apeng Chen; Shaorong Liu

doi:10.1016/j.talanta.2017.09.016

Miniaturized high-performance liquid chromatography instrumentation

Talanta. 2018 Jan 15:177:94-103. doi: 10.1016/j.talanta.2017.09.016. Epub 2017 Sep 14.

Authors

Kyle B Lynch¹, Apeng Chen², Shaorong Liu²

Affiliations

¹ Department of Chemistry and Biochemistry, University of Oklahoma, USA. Electronic address: lynchkb@ou.edu.
² Department of Chemistry and Biochemistry, University of Oklahoma, USA.

PMID: 29108588
DOI: 10.1016/j.talanta.2017.09.016

Abstract

Miniaturized high performance liquid chromatography (HPLC) has attracted increasing attention for its potential in high-throughput analyses and point-of-care applications. In this review we highlight the recent advancements in HPLC system miniaturization. We focus on the major components that constitute these instruments along with their respective advantages and drawbacks as well as present a few representative miniaturized HPLC systems. We discuss briefly some of the applications and also anticipate the future development trends of these instrumental platforms.

Keywords: Electroosmotic pump; Gradient generator; High performance liquid chromatography; Miniaturized; Nanoflow.