A global function for transcription factors in assisting RNA polymerase II termination

Kevin Roy; Guillaume F Chanfreau

doi:10.1080/21541264.2017.1300121

A global function for transcription factors in assisting RNA polymerase II termination

Transcription. 2018;9(1):41-46. doi: 10.1080/21541264.2017.1300121. Epub 2017 Nov 6.

Authors

Kevin Roy¹, Guillaume F Chanfreau¹

Affiliation

¹ a Department of Chemistry and Biochemistry and the Molecular Biology Institute , University of California Los Angeles , CA , USA.

Abstract

The role of transcription factors (TFs) on nucleosome positioning, RNA polymerase recruitment, and transcription initiation has been extensively characterized. Here, we propose that a subset of TFs such as Reb1, Abf1, Rap1, and TFIIIB also serve a major function in partitioning transcription units by assisting the Nrd1p-Nab3p-Sen1p Pol II termination pathway.

Keywords: GRFs; Nab3; Nrd1; Reb1; Sen1; TFIIIB; Transcription termination; exosome.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Humans
RNA Polymerase II / metabolism*
Transcription Factors / metabolism*
Transcription Termination, Genetic*

Substances

Transcription Factors
RNA Polymerase II