Enhanced physical endurance and improved memory performance following taurine administration in rats

Pak J Pharm Sci. 2017 Sep;30(5(Supplementary)):1957-1963.

Abstract

Energy drinks enhance physical endurance and cognitive ability. The ingredients present in these drinks are considered as ergogenic and have memory boosting effects. In the present study effects of taurine administration for one week was monitored on physical exercise and memory performance in rats. Animals were divided into two groups namely control and test. Taurine was injected intraperitoneally to the test group at the dose of 100mg/kg. After one week of treatment rats were subjected to physical exercise and memory task. Results of this study revealed that rats injected with taurine for one week exhibited improved muscular strength as well as enhanced memory performance in Morris water maze and elevated plus maze. Biomarker of lipid peroxidation was significantly reduced in brain and plasma of test animals. Taurine administration also resulted in higher levels of corticosterone in this study. The results highlight the significance of taurine ingestion in energy demanding and challenging situations in athletes and young subjects.

MeSH terms

  • Animals
  • Behavior, Animal / drug effects*
  • Brain / drug effects
  • Brain / metabolism
  • Catalase / metabolism
  • Drug Administration Schedule
  • Hydrocortisone / blood
  • Injections, Intraperitoneal
  • Lipid Peroxidation / drug effects
  • Malondialdehyde / metabolism
  • Maze Learning / drug effects
  • Memory / drug effects*
  • Muscle Strength / drug effects
  • Muscle, Skeletal / drug effects*
  • Muscle, Skeletal / physiology
  • Physical Endurance / drug effects*
  • Rats, Wistar
  • Taurine / administration & dosage*
  • Time Factors

Substances

  • Taurine
  • Malondialdehyde
  • Catalase
  • Hydrocortisone