Synthesis and biological evaluation of thiazole derivatives as GPR119 agonists

Bioorg Med Chem Lett. 2017 Dec 1;27(23):5213-5220. doi: 10.1016/j.bmcl.2017.10.046. Epub 2017 Oct 20.

Abstract

A series of 4-(phenoxymethyl)thiazole derivatives was synthesized and evaluated for their GPR119 agonistic effect. Several 4-(phenoxymethyl)thiazoles with pyrrolidine-2,5-dione moieties showed potent GPR119 agonistic activities. Among them, compound 27 and 32d showed good in vitro activity with an EC50 value of 49 nM and 18 nM, respectively with improved human and rat liver microsomal stability compare with MBX-2982. Compound 27 &32d did not exhibit significant CYP inhibition, hERG binding, and cytotoxicity. Moreover, these compounds lowered the glucose excursion in mice in an oral glucose-tolerance test.

Keywords: 4-(Phenoxymethyl)thiazole; GPR119 agonists; OGTT; Pyrrolidine-2,5-dione; Type 2 diabetes.

MeSH terms

  • Animals
  • Cell Line
  • Chlorocebus aethiops
  • Cricetulus
  • Dose-Response Relationship, Drug
  • Humans
  • Mice
  • Microsomes, Liver / chemistry
  • Microsomes, Liver / metabolism
  • Molecular Structure
  • Rats
  • Receptors, G-Protein-Coupled / agonists*
  • Structure-Activity Relationship
  • Thiazoles / chemical synthesis
  • Thiazoles / chemistry
  • Thiazoles / pharmacology*

Substances

  • GPR119 protein, human
  • Receptors, G-Protein-Coupled
  • Thiazoles