Left Heart Disease and Pulmonary Hypertension: Are We Seeing the Full Picture?

Heart Lung Circ. 2018 Mar;27(3):301-309. doi: 10.1016/j.hlc.2017.09.015. Epub 2017 Oct 20.

Abstract

Pulmonary hypertension (PH) is common, under diagnosed and associated with a high mortality. There are significant delays in the diagnosis of pulmonary hypertension leading to increased morbidity and delays in the initiation of treatment. Once PH is diagnosed, establishing the degree of pulmonary vascular resistance (PVR) enables clinicians to broadly divide the underlying pathology into pre-capillary or post-capillary causes, a crucial step in tailoring management. Pulmonary hypertension is most commonly due to left heart disease (PH-LHD) and echocardiography (echo) is the most widely accessible investigation in its diagnosis. Regardless of the underlying pathophysiology of LHD, the sequelae lead to pressure overload on the left heart and a reactive increase in pulmonary pressures. In this review article, we will discuss the prevalence of PH, examine the pathophysiology of PH-LHD, establish how echo can be used to identify patients with PH-LHD and discuss surrogate echo markers of PVR.

Keywords: Diastolic dysfunction; Echocardiography; Heart failure with preserved ejection fraction (HFpEF); Left heart disease (LHD); Pulmonary hypertension (PH); Pulmonary vascular resistance (PVR).

Publication types

  • Review

MeSH terms

  • Diastole
  • Echocardiography
  • Heart Failure* / complications
  • Heart Failure* / diagnosis
  • Heart Failure* / physiopathology
  • Humans
  • Hypertension, Pulmonary* / diagnosis
  • Hypertension, Pulmonary* / etiology
  • Hypertension, Pulmonary* / physiopathology
  • Pulmonary Wedge Pressure / physiology*
  • Stroke Volume
  • Ventricular Function, Left / physiology*