A Sweet Deal for Diabetes

Matteo Villa; Jing Qiu; Erika L Pearce

doi:10.1016/j.tem.2017.10.006

A Sweet Deal for Diabetes

Trends Endocrinol Metab. 2018 Jan;29(1):1-2. doi: 10.1016/j.tem.2017.10.006.

Authors

Matteo Villa¹, Jing Qiu¹, Erika L Pearce²

Affiliations

¹ Department of Immunometabolism, Max Planck Institute of Immunobiology and Epigenetics, Freiburg im Breisgau, Germany; These authors contributed equally to this work.
² Department of Immunometabolism, Max Planck Institute of Immunobiology and Epigenetics, Freiburg im Breisgau, Germany. Electronic address: pearce@ie-freiburg.mpg.de.

PMID: 29102469
DOI: 10.1016/j.tem.2017.10.006

Abstract

Sugars have pathogenic roles in diabetes. In Nature Medicine, Zhang et al. revisit this dogma and show that mannose induces the generation of regulatory T (Treg) cells. The immunoregulatory effect of mannose not only prevented the onset of autoimmune diabetes but also blocked disease progression in new-onset diabetic mice.

Keywords: autoimmune disease; fatty acid oxidation; latent TGF-β; mannose; reactive oxygen species; regulatory T cells.

Publication types

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MeSH terms

Animals
Diabetes Mellitus, Experimental*
Diabetes Mellitus, Type 1
Mice
T-Lymphocytes, Regulatory
Transforming Growth Factor beta*

Substances

Transforming Growth Factor beta