Origin of Uterine Fibroids: Conversion of Myometrial Stem Cells to Tumor-Initiating Cells

Semin Reprod Med. 2017 Nov;35(6):481-486. doi: 10.1055/s-0037-1607205. Epub 2017 Nov 3.

Authors

Hoda Elkafas^{1

2}, Yang Qiwei², Ayman Al-Hendy²

Affiliations

¹ Pharmacology and Toxicology Department, National Organization for Drug Control and Research (NODCAR), Giza, Egypt.
² Obsteric and Gynecology Department, Medical College of Georgia, Augusta University, Augusta, Georgia.

PMID: 29100235
DOI: 10.1055/s-0037-1607205

No abstract available

Publication types

Review

MeSH terms

Adult Stem Cells / drug effects
Adult Stem Cells / metabolism
Adult Stem Cells / pathology*
Cell Transformation, Neoplastic / drug effects
Cell Transformation, Neoplastic / metabolism
Cell Transformation, Neoplastic / pathology*
Endocrine Disruptors / toxicity
Epigenesis, Genetic / drug effects
Female
Genetic Predisposition to Disease
Humans
Leiomyoma / chemically induced
Leiomyoma / genetics
Leiomyoma / metabolism
Leiomyoma / pathology*
Leiomyomatosis / chemically induced
Leiomyomatosis / genetics
Leiomyomatosis / metabolism
Leiomyomatosis / pathology*
Mutation
Myometrium / drug effects
Myometrium / metabolism
Myometrium / pathology*
Neoplasm Proteins / genetics
Neoplasm Proteins / metabolism
Neoplastic Stem Cells / drug effects
Neoplastic Stem Cells / metabolism
Neoplastic Stem Cells / pathology*
Uterine Neoplasms / chemically induced
Uterine Neoplasms / genetics
Uterine Neoplasms / metabolism
Uterine Neoplasms / pathology*

Substances

Endocrine Disruptors
Neoplasm Proteins