Role of LFA-1 and ICAM-1 in Cancer

Manuel Reina; Enric Espel

doi:10.3390/cancers9110153

Role of LFA-1 and ICAM-1 in Cancer

Cancers (Basel). 2017 Nov 3;9(11):153. doi: 10.3390/cancers9110153.

Authors

Manuel Reina^{1

2}, Enric Espel^{3

4}

Affiliations

¹ Department of Cell Biology, Physiology and Immunology, Faculty of Biology, University of Barcelona, Diagonal 643, 08028 Barcelona, Spain. mreina@ub.edu.
² Celltec UB, Faculty of Biology, University of Barcelona, Diagonal 643, 08028 Barcelona, Spain. mreina@ub.edu.
³ Department of Cell Biology, Physiology and Immunology, Faculty of Biology, University of Barcelona, Diagonal 643, 08028 Barcelona, Spain. eespel@ub.edu.
⁴ Celltec UB, Faculty of Biology, University of Barcelona, Diagonal 643, 08028 Barcelona, Spain. eespel@ub.edu.

Abstract

The lymphocyte function-associated antigen-1 (LFA-1) (also known as CD11a/CD18 and α_Lβ₂), is just one of many integrins in the human body, but its significance is derived from its exclusive presence in leukocytes. In this review, we summarize the studies relating LFA-1 and its major ligand ICAM-1 (or CD54) with cancer, through the function of lymphocytes and myeloid cells on tumor cells. We consider how LFA-1 mediates the interaction of leukocytes with tumors and the role of ICAM-1 in tumor dynamics, which can be independent of its interaction with LFA-1. We also offer a more detailed examination of the role of LFA-1 within B-cell chronic lymphocytic leukemia. Finally, we discuss the role that exosomes harboring LFA-1 play in tumor growth and metastasis.

Keywords: cancer metastasis; chronic lymphocytic leukemia; exosomes; tumor microenvironment.

Publication types

Review