1 aUniversity of Milano Bicocca, Milano, Italy bHospital Clinic University of Barcelona, Barcelona, Spain cDepartment of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy dCenter for Cardiovascular Prevention, First Faculty of Medicine and Thomayer Hospital, Charles University in Prague, Prague, Czech Republic eDepartment of Cardiology, "Asklepeion" General Hospital, Athens, Greece fINCLIVA Research Institute, University of Valencia and CIBERObn, ISCIII, Madrid, Spain.