Epidemiology of Pediatric Zika Virus Infections

Pediatrics. 2017 Dec;140(6):e20172044. doi: 10.1542/peds.2017-2044. Epub 2017 Nov 1.

Abstract

Background and objective: In July 2016, local transmission of Zika virus (ZIKV) was announced in Miami-Dade County, Florida. In this report, we describe the epidemiology of pediatric ZIKV infections in locally acquired and travel-associated cases.

Methods: All children aged 1 to 17 years tested for ZIKV between October 1, 2015, and March 29, 2017, were included. SAS 9.4 was used to analyze age, sex, race and/or ethnicity, origin of exposure, onset date, affiliation with a household cluster, clinical symptoms, hospitalizations, viremia, viruria, and antibody detection in specimens.

Results: Among 478 confirmed ZIKV cases in Miami-Dade County, 33 (6.9%) occurred in children (1-17 years). Twenty-seven (82.3%) cases were travel-associated. The median age of a pediatric Zika case patient was 11 years. Seventeen (51.5%) case patients were boys, and 23 (69.9%) were Hispanic. Among 31 symptomatic cases, all reported having rash, 25 (80.6%) reported fever, 9 (29.0%) reported conjunctivitis, and 7 (22.6%) reported arthralgia. Sixteen (48.5%) cases reported 2 of 4 and 8 (24.2%) reported 3 of 4 main symptoms.

Conclusions: This report found that the majority of children identified during the 2016 ZIKV outbreak only presented with 2 of the 4 main symptoms. In addition, pediatric ZIKV cases were frequently associated with symptomatic household members.

MeSH terms

  • Adolescent
  • Age Factors
  • Antibodies, Viral / analysis
  • Child
  • Child, Preschool
  • DNA, Viral / analysis
  • Disease Outbreaks*
  • Ethnicity*
  • Female
  • Florida / epidemiology
  • Humans
  • Infant
  • Male
  • Morbidity / trends
  • Retrospective Studies
  • Risk Assessment / methods*
  • Sex Factors
  • Zika Virus / genetics
  • Zika Virus / immunology
  • Zika Virus Infection / diagnosis
  • Zika Virus Infection / ethnology*
  • Zika Virus Infection / virology

Substances

  • Antibodies, Viral
  • DNA, Viral