Common Variations in Perilipin rs1052700 and FTO rs3751812 Gene Variants, and Risk for Obesity and Type-2 Diabetes

Ramin Saravani; Hamid Reza Galavi; Nafiseh Noorzehi; Nasrin Ranjbar; Fatemeh Mollashahee-Kohkan

Common Variations in Perilipin rs1052700 and FTO rs3751812 Gene Variants, and Risk for Obesity and Type-2 Diabetes

Rep Biochem Mol Biol. 2017 Oct;6(1):80-87.

Authors

Ramin Saravani^{1

2}, Hamid Reza Galavi^{1

2}, Nafiseh Noorzehi³, Nasrin Ranjbar², Fatemeh Mollashahee-Kohkan²

Affiliations

¹ Cellular and Molecular Research Center, Zahedan University of Medical Sciences, Zahedan, Iran.
² Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
³ Department of Biology, Zabol University, Zabol, Iran.

PMID: 29090233
PMCID: PMC5643444

Abstract

Background: Perilipins are proteins that coat lipid globules in adipocytes, which are steroid-generating cells that play a central role in lipid storage and breakdown. The FTO gene is associated with type-2 diabetes (T2D) and increased fat mass. In this work the association of perilipin and FTO gene polymorphisms in T2D was investigated.

Methods: One hundred eighty-three Iranian men and women with T2D, and 174 healthy controls with no known metabolic diseases, participated in the study. The subjects were genotyped using tetra-primer amplification refractory mutation system-polymerase chain reaction (Tetra-ARMS-PCR) and their clinical traits were analyzed.

Results: A significant association was found between the perilipin rs1052700 polymorphism and T2D, and between the FTO rs3751812 polymorphism and obesity (P = 0.03 and 0.003, respectively); however, no significant relationship was found between rs3751812 and T2D.

Conclusion: The FTO rs3751812 polymorphism is a major genetic determinant of obesity, but not T2D. The perilipin rs1052700 polymorphism is related to T2D but not obesity.

Keywords: FTO; Gene polymorphism; Perilipin; Type-2 diabetes.