New Kid on the Block: LmbU Expands the Repertoire of Specialized Metabolic Regulators in Streptomyces

Kou-San Ju; Xiafei Zhang; Marie A Elliot

doi:10.1128/JB.00559-17

New Kid on the Block: LmbU Expands the Repertoire of Specialized Metabolic Regulators in Streptomyces

J Bacteriol. 2017 Dec 20;200(2):e00559-17. doi: 10.1128/JB.00559-17. Print 2018 Jan 15.

Authors

Kou-San Ju^{1

2}, Xiafei Zhang³, Marie A Elliot⁴

Affiliations

¹ Department of Microbiology, The Ohio State University, Columbus, Ohio, USA ju.109@osu.edu melliot@mcmaster.ca.
² Division of Medicinal Chemistry and Pharmacognosy, The Ohio State University, Columbus, Ohio, USA.
³ Department of Biology, and M.G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, ON, Canada.
⁴ Department of Biology, and M.G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, ON, Canada ju.109@osu.edu melliot@mcmaster.ca.

Abstract

Streptomyces has an extensive natural product repertoire, including most of the naturally derived antibiotics. Understanding the control of natural product biosynthesis is central to antibiotic discovery and production optimization. Here, Hou et al. (J. Bacteriol. 200:00447-17, 2018, https://doi.org/10.1128/JB.00447-17) report the identification and characterization of a novel regulator-LmbU-that functions primarily as an activator of lincomycin production in Streptomyces lincolnensis Importantly, members of this new regulator family are associated with natural product biosynthetic clusters throughout the streptomycetes and their actinomycete relatives.

Keywords: Streptomyces; antibiotic; cluster-situated regulator; lincomycin; natural product; regulator; transcription factor.

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MeSH terms

Anti-Bacterial Agents
Gene Expression Regulation, Bacterial*
Lincomycin
Streptomyces*

Substances

Anti-Bacterial Agents
Lincomycin