Since the comprehensive two-dimensional gas chromatography (GC × GC) technique is becoming more and more available for scientists as well as for laboratories performing routine analyses, the most successful field of applications are petrochemical, food and essential oil analysis. However, this technique coupled with TOF-MS (P.1, l. 27) could be even more successfully used in the field of metabolomics. The review presents briefly the concept of comprehensive 2D GC and the principles of the technique. Certain specific applications are discussed to show the usefulness of GC × GC combined with different detectors for determination of compounds not always easy to measure with other techniques.
Keywords: Comprehensive gas chromatography; mass spectrometry; volatile organic compounds.