13C Satellite-Free 1H NMR Spectra

Anal Chem. 2017 Nov 21;89(22):11898-11901. doi: 10.1021/acs.analchem.7b03787. Epub 2017 Nov 7.

Abstract

A new NMR experiment (Destruction of Interfering Satellites by Perfect Echo Low-pass filtration, DISPEL) is introduced that facilitates the analysis of low-level components in high dynamic range mixtures by suppressing one-bond 13C satellite signals in 1H spectra. Since the natural abundance of 13C is around 1.1%, these satellites appear at 0.54% of the intensity of a parent peak, mimicking and often masking impurity signals. The new experiment suppresses one-bond 13C satellite signals, with high efficiency, at negligible cost in signal-to-noise ratio, and over a wide range of one-bond coupling constants, without the need for broadband 13C decoupling.

Publication types

  • Research Support, Non-U.S. Gov't