Predicting the role of microstructural and biomechanical cues in tumor growth and spreading

Abstract

A continuum porous media model is developed for elucidating the role of the mechanical cues in regulating tumor growth and spreading. It is shown that stiffer matrices and higher cell-matrix adhesion limit tumor growth and spreading toward the surrounding tissue. Higher matrix porosities, conversely, favor the growth and the dissemination of tumor cells. This model could be used for predicting the response of malignant masses to novel therapeutic agents affecting directly the tumor microenvironment and its micromechanical cues.

Keywords: cell adhesion; computational modeling; matrix porosity; metastasis; tissue mechanics.