Porphyrin- or phthalocyanine-bridged silsesquioxane nanoparticles for two-photon photodynamic therapy or photoacoustic imaging

Chiara Mauriello-Jimenez; Maxime Henry; Dina Aggad; Laurence Raehm; Xavier Cattoën; Michel Wong Chi Man; Clarence Charnay; Serkan Alpugan; Vefa Ahsen; Deniz Kutlu Tarakci; Philippe Maillard; Marie Maynadier; Marcel Garcia; Fabienne Dumoulin; Magali Gary-Bobo; Jean-Luc Coll; Véronique Josserand; Jean-Olivier Durand

doi:10.1039/c7nr04677d

Porphyrin- or phthalocyanine-bridged silsesquioxane nanoparticles for two-photon photodynamic therapy or photoacoustic imaging

Nanoscale. 2017 Nov 9;9(43):16622-16626. doi: 10.1039/c7nr04677d.

Authors

Chiara Mauriello-Jimenez¹, Maxime Henry, Dina Aggad, Laurence Raehm, Xavier Cattoën, Michel Wong Chi Man, Clarence Charnay, Serkan Alpugan, Vefa Ahsen, Deniz Kutlu Tarakci, Philippe Maillard, Marie Maynadier, Marcel Garcia, Fabienne Dumoulin, Magali Gary-Bobo, Jean-Luc Coll, Véronique Josserand, Jean-Olivier Durand

Affiliation

¹ Institut Charles Gerhardt Montpellier, UMR-5253 CNRS-UM-ENSCM, cc 1701, Place Eugène Bataillon, 34095 Montpellier Cedex 05, France. durand@univ-montp2.fr.

PMID: 29082396
DOI: 10.1039/c7nr04677d

Abstract

Porphyrin- or phthalocyanine-bridged silsesquioxane nanoparticles (BSPOR and BSPHT) were prepared. Their endocytosis in MCF-7 cancer cells was shown with two-photon excited fluorescence (TPEF) imaging. With two-photon excited photodynamic therapy (TPE-PDT), BSPOR was more phototoxic than BSPHT, which in contrast displayed a very high signal for photoacoustic imaging in mice.