Chromophore decomposition in multispectral time-resolved diffuse optical tomography

Biomed Opt Express. 2017 Sep 28;8(10):4772-4787. doi: 10.1364/BOE.8.004772. eCollection 2017 Oct 1.

Abstract

Multicomponent phantom measurements are carried out to evaluate the ability of multispectral time domain diffuse optical tomography in reflectance geometry to quantify the position and the composition of small heterogeneities at depths of 1-1.5 cm in turbid media. Time-resolved data were analyzed with the Mellin-Laplace transform. Results show good localization and correct composition gradation of objects but still a lack of absolute material composition accuracy when no a priori geometry information is known.

Keywords: (030.5260) Photon counting; (100.3010) Image reconstruction techniques; (110.0113) Imaging through turbid media; (110.6960) Tomography; (170.6920) Time-resolved imaging; (230.5160) Photodetectors.