Intra-ocular lens optical changes resulting from the loading of dexamethasone

José M Artigas; M Carmen García-Domene; Amparo Navea; Pablo Botella; Eduardo Fernández

doi:10.1364/BOE.8.004621

Intra-ocular lens optical changes resulting from the loading of dexamethasone

Biomed Opt Express. 2017 Sep 21;8(10):4621-4628. doi: 10.1364/BOE.8.004621. eCollection 2017 Oct 1.

Authors

José M Artigas^{1

2}, M Carmen García-Domene^{1

2}, Amparo Navea^{1

3}, Pablo Botella⁴, Eduardo Fernández⁵

Affiliations

¹ Fisabio Oftalmología Médica (FOM), Bifurcación Pío Baroja-General Avilés s/n, 46015 Valencia, Spain.
² Depto de Óptica, Facultad de Física, Universitat de València, C/Dr Moliner, 50, 46100 Burjassot (Valencia), Spain.
³ Universidad Cardenal Herrera-CEU, Castellón, Spain.
⁴ Instituto de Tecnología Química (ITQ), Universitat Politècnica de València-Consejo Superior de Investigaciones Científicas, Avenida de los Naranjos s/n, 46022 Valencia, Spain.
⁵ Instituto de Bioingeniería, Universidad Miguel Hernández and CIBER BBN, Elche, Spain.

Abstract

To study the optical changes on hydrogel-silicone intraocular lenses (IOLs) resulting from loading them with dexamethasone. We used prototype hydrogel(pHEMA)-silicone IOLs and loaded the matrices with an anti-inflammatory drug (dexamethasone). The optical properties we analyzed experimentally were a) modulation transfer function (MTF); b) spectral transmission; c) diopter power. These determinations were performed on drug-loaded IOLs, IOLs that had released the drug, and IOLs that had not been drug-loaded. Loading a hydrogel-silicone IOL with dexamethasone results in impairment of its optical qualities, in particular its MTF and spectral transmission, but not dioptric power. However, once the drug has been released, it almost recovers its initial optical properties.

Keywords: (170.0170) Medical optics and biotechnology; (170.4470) Ophthalmology; (330.4460) Ophthalmic optics and devices.