18F-FDG PET for Detection of Primary Tracheobronchial T-/Natural Killer-Cell-Derived Posttransplant Lymphoproliferative Disorder After Lung Transplantation

Clin Nucl Med. 2017 Dec;42(12):988-989. doi: 10.1097/RLU.0000000000001876.

Abstract

Posttransplant lymphoproliferative disorder (PTLD) is a rare, but potentially devastating complication of solid organ transplantation. Epstein-Barr virus-associated PTLDs of T-cell origin are exceedingly rare. We present the case of a 20-year-old man with extranasal T-/natural killer-cell-derived PTLD after lung transplantation who underwent an F-FDG PET/CT scan for staging of disease. The F-FDG-PET scan demonstrated an unusual pattern of lymphomatous involvement limited to the recipients tracheobronchial tree without concomitant involvement of the donor's bronchi. This case highlights the potential of F-FDG PET/CT for sensitive detection and staging of uncommon manifestations of PTLD.

Publication types

  • Case Reports

MeSH terms

  • Bronchi / immunology*
  • Fluorodeoxyglucose F18*
  • Humans
  • Lung Transplantation / adverse effects*
  • Lymphoproliferative Disorders / diagnostic imaging*
  • Lymphoproliferative Disorders / etiology
  • Lymphoproliferative Disorders / immunology
  • Male
  • Natural Killer T-Cells / immunology*
  • Positron-Emission Tomography*
  • Trachea / immunology*
  • Young Adult

Substances

  • Fluorodeoxyglucose F18