Divergent evolutionary trajectories in transplanted tumor models

Carlos Villacorta-Martin; Amanda J Craig; Augusto Villanueva

doi:10.1038/ng.3983

Divergent evolutionary trajectories in transplanted tumor models

Nat Genet. 2017 Oct 27;49(11):1565-1566. doi: 10.1038/ng.3983.

Authors

Carlos Villacorta-Martin¹, Amanda J Craig¹, Augusto Villanueva^{1

2}

Affiliations

¹ Liver Cancer Research Program, Division of Liver Diseases, Tisch Cancer Institute, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
² Division of Hematology and Medical Oncology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

PMID: 29074950
DOI: 10.1038/ng.3983

Abstract

Human-derived tumor models are becoming popular in the context of personalized medicine, but a new study shows that these models could be less representative of primary tumors than previously thought, particularly when using late passages.

MeSH terms

Animals
Clonal Evolution*
Clone Cells
DNA Copy Number Variations
DNA, Neoplasm / genetics
DNA, Neoplasm / immunology*
Disease Models, Animal
Heterografts / immunology*
Heterografts / pathology
Humans
Immunocompromised Host*
Mice
Neoplasms / genetics
Neoplasms / immunology*
Neoplasms / metabolism
Neoplasms / pathology
Precision Medicine
Species Specificity
Tumor Cells, Cultured

Substances

DNA, Neoplasm