Fully Artificial Exosomes: Towards New Theranostic Biomaterials

Pablo García-Manrique; Gemma Gutiérrez; Maria Carmen Blanco-López

doi:10.1016/j.tibtech.2017.10.005

Fully Artificial Exosomes: Towards New Theranostic Biomaterials

Trends Biotechnol. 2018 Jan;36(1):10-14. doi: 10.1016/j.tibtech.2017.10.005. Epub 2017 Oct 23.

Authors

Pablo García-Manrique¹, Gemma Gutiérrez², Maria Carmen Blanco-López³

Affiliations

¹ Department of Chemical and Environmental Engineering, University of Oviedo, Julián Clavería 8, 33006 Oviedo, Spain; Department of Physical and Analytical Chemistry, University of Oviedo, Julián Clavería 8, 33006 Oviedo, Spain.
² Department of Chemical and Environmental Engineering, University of Oviedo, Julián Clavería 8, 33006 Oviedo, Spain.
³ Department of Physical and Analytical Chemistry, University of Oviedo, Julián Clavería 8, 33006 Oviedo, Spain. Electronic address: cblanco@uniovi.es.

PMID: 29074309
DOI: 10.1016/j.tibtech.2017.10.005

Abstract

Bionanotechnology routes have been recently developed to produce fully artificial exosomes: biomimetic particles designed to overcome certain limitations in extracellular vesicle (EV) biology and applications. These particles could soon become true therapeutic biomaterials. Here, we outline their current preparation techniques, their explored and future possibilities, and their present limits.

Keywords: artificial exosomes; bio-nanotechnology; biomimetic material; extracellular vesicles; nanomedicine.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Biocompatible Materials / chemical synthesis*
Biocompatible Materials / metabolism*
Biological Therapy / methods
Exosomes / metabolism*
Humans
Molecular Medicine / methods*
Theranostic Nanomedicine / methods*

Substances

Biocompatible Materials