Successful Treatment with 5-fluorouracil and Levofolinate Calcium in Advanced Gastric Cancer Patient with Disseminated Intravascular Coagulation

Osamu Muto; Masaki Munakata; Kenki Yamagata; Akio Masuda; Kei Kotanagi; Takuya Kichiraku; Rika Satoyoshi; Kazuhiro Kudoh; Toshiya Sawada; Hideaki Miyazawa; Shinichiro Ouchi; Hitoshi Kotanagi; Yuh Sakata

Successful Treatment with 5-fluorouracil and Levofolinate Calcium in Advanced Gastric Cancer Patient with Disseminated Intravascular Coagulation

Gan To Kagaku Ryoho. 2017 Oct;44(10):867-869.

Authors

Osamu Muto¹, Masaki Munakata, Kenki Yamagata, Akio Masuda, Kei Kotanagi, Takuya Kichiraku, Rika Satoyoshi, Kazuhiro Kudoh, Toshiya Sawada, Hideaki Miyazawa, Shinichiro Ouchi, Hitoshi Kotanagi, Yuh Sakata

Affiliation

¹ Dept. of Medical Oncology, Akita Red Cross Hospital.

PMID: 29066681

Abstract

A 32-year-old woman was found to have a gastric adenocarcinoma with multiple bone metastases. Chemotherapy in the first, second and third-line was not effective. Blood examinations showed disseminated intravascular coagulation(DIC)at the end of the second-line chemotherapy. The fourth-line chemotherapy, infusional 5-fluorouracil and levofolinate calcium was performed. This resulted in a good response for DIC. This palliative therapy was effective and safety.

Publication types

Case Reports

MeSH terms

Adenocarcinoma / complications
Adenocarcinoma / drug therapy*
Adenocarcinoma / surgery
Adult
Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
Disseminated Intravascular Coagulation / etiology*
Female
Fluorouracil / administration & dosage
Gastrectomy
Humans
Levoleucovorin / administration & dosage
Stomach Neoplasms / complications
Stomach Neoplasms / drug therapy*
Stomach Neoplasms / pathology
Stomach Neoplasms / surgery
Treatment Outcome

Substances

Levoleucovorin
Fluorouracil