Abstract
Human polyomavirus-7-associated rash and pruritus (PVARP) is a chronic superficial viral skin infection, which primarily impacts immunocompromised individuals. We report on a case of PVARP in a lung transplant recipient. Our patient developed symptoms 13 years after being on his immunosuppressive regimen, with an insidious course of progressive gray lichenification with marked islands of sparing and quality of life-altering pruritus. Treatment for PVARP is not established; however, topical cidofovir combined with immunomodulation may offer sustained therapeutic benefit.
Keywords:
cidofovir; human polyomavirus-7; peacock plumage; pruritus; rash; solid organ transplantation.
© 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
MeSH terms
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Administration, Topical
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Adult
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Aged
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Antiviral Agents / administration & dosage
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Antiviral Agents / therapeutic use
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BK Virus / drug effects*
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Cidofovir
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Cytosine / administration & dosage
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Cytosine / analogs & derivatives*
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Cytosine / therapeutic use
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Exanthema / drug therapy
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Exanthema / virology
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Female
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Humans
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Immunocompromised Host
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Immunosuppressive Agents / therapeutic use
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Lung Transplantation / adverse effects*
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Male
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Middle Aged
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Organophosphonates / administration & dosage
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Organophosphonates / therapeutic use*
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Polyomavirus Infections / drug therapy*
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Polyomavirus Infections / etiology
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Pruritus / drug therapy
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Pruritus / virology
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Transplant Recipients
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Tumor Virus Infections / drug therapy*
Substances
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Antiviral Agents
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Immunosuppressive Agents
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Organophosphonates
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Cytosine
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Cidofovir