Effects of Multicide, Antibacterial Drug, on Staphylococcus Biomembranes

Bull Exp Biol Med. 2017 Oct;163(6):780-784. doi: 10.1007/s10517-017-3902-z. Epub 2017 Oct 24.

Abstract

Drug penetration into bacterial biomembranes is one of the most important factors determining the efficiency of antibacterial therapy. Multicide, antibacterial drug, is a nanomolecule 1.3-2.0 nm in size, easily penetrating into staphylococcus biomembranes and causing rapid death of bacteria. The drug efficiency depends on its concentration and duration of exposure. Bacteria die as a result of cell wall perforation, which is associated with changes in its morphology and release of DNA from bacterial cell into the environment. Our results indicate the efficiency of primary damage to bacterial wall leading to elimination of biomembranes.

Keywords: antibacterial drugs; bacteria; biomembranes; nanomolecule.

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Cell Membrane / drug effects*
  • Cell Membrane / metabolism
  • Cell Membrane / ultrastructure
  • Cell Wall / drug effects*
  • Cell Wall / metabolism
  • Cell Wall / ultrastructure
  • Microscopy, Electron
  • Permeability
  • Staphylococcus aureus / drug effects*
  • Staphylococcus aureus / metabolism
  • Staphylococcus aureus / ultrastructure

Substances

  • Anti-Bacterial Agents