Systems metabolic engineering strategies for the production of amino acids

Qian Ma; Quanwei Zhang; Qingyang Xu; Chenglin Zhang; Yanjun Li; Xiaoguang Fan; Xixian Xie; Ning Chen

doi:10.1016/j.synbio.2017.07.003

Systems metabolic engineering strategies for the production of amino acids

Synth Syst Biotechnol. 2017 Aug 2;2(2):87-96. doi: 10.1016/j.synbio.2017.07.003. eCollection 2017 Jun.

Authors

Qian Ma^{1

2

3}, Quanwei Zhang³, Qingyang Xu^{1

2

3}, Chenglin Zhang^{1

2

3}, Yanjun Li^{1

2

3}, Xiaoguang Fan^{1

2

3}, Xixian Xie^{1

2

3}, Ning Chen^{1

2

3}

Affiliations

¹ National and Local United Engineering Lab of Metabolic Control Fermentation Technology, Tianjin University of Science and Technology, Tianjin, 300457, China.
² Key Laboratory of Industrial Fermentation Microbiology, Ministry of Education, Tianjin University of Science and Technology, Tianjin, 300457, China.
³ College of Biotechnology, Tianjin University of Science and Technology, Tianjin, 300457, China.

Abstract

Systems metabolic engineering is a multidisciplinary area that integrates systems biology, synthetic biology and evolutionary engineering. It is an efficient approach for strain improvement and process optimization, and has been successfully applied in the microbial production of various chemicals including amino acids. In this review, systems metabolic engineering strategies including pathway-focused approaches, systems biology-based approaches, evolutionary approaches and their applications in two major amino acid producing microorganisms: Corynebacterium glutamicum and Escherichia coli, are summarized.

Keywords: Amino acid; Corynebacterium glutamicum; Escherichia coli; Systems metabolic engineering.

Publication types

Review